Líneas de Investigación

Líneas de Investigación

Neurociencia Cognitiva y Salud Mental

Investigador/a Principal: 

Objetivos del equipo de investigación

En nuestro equipo buscamos llegar a una mejor comprensión acerca de como funcionan problemáticas de la salud mental como la depresión o la ansiedad social, con el fin de que a largo plazo este conocimiento de lugar a mejores tratamientos. En particular, buscamos entender como funcionan estos trastornos en cuanto a la toma de decisiones y al funcionamiento cerebral. Con este fin, trabajamos desarrollando experimentos psicológicos y utilizamos las técnicas de la resonancia magnética funcional (fMRI) y la electroencefalografía (EEG), que permiten explorar el funcionamiento cerebral en humanos.


Aims of the research team

In our team we aim to reach a better understanding of how mental health disorders such as depression or social anxiety work, so that in the long term this knowledge leads to better treatments. In particular, we seek to understand how these disorders work in terms of decision-making and brain function. To this end, we work developing psychological experiments and use techniques such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), which allow exploration of brain function in humans.

 

Publicaciones 

2022

Uriarte-Gaspari, L., Acuña, A., Morales, S., Fernández-Theoduloz, G., Paz, V., Pérez, A., & Gradin, V.B. (2022). Who do I want in my team: social avoidance of high qualified partners in depression and social anxiety. Journal of Affective Disorders Report 10. 
 

2021

Cervantes Constantino, F., Garat, S., Nicolaisen-Sobesky, E., Paz, V., Martínez-Montes, E., Kessel, D., Cabana, Á., & Gradin, V. B. (2021). Neural processing of iterated prisoner’s dilemma outcomes indicates next-round choice and speed to reciprocate cooperation. Social Neuroscience, 16(2): 103-120 https://doi.org/10.1080/17470919.2020.1859410

 

2019

Fernández-Theoduloz, G., Paz, V., Nicolaisen-Sobesky, E., Pérez, A., Buunk, A. P., Cabana, Á., & Gradin, V. B. (2019). Social avoidance in depression: A study using a social decision-making task. Journal of Abnormal Psychology, 128(3), 234–244. https://doi.org/10.1037/abn0000415

 

2017

Paz, V., Nicolaisen-Sobesky, E., Collado, E., Horta, S., Rey, C., Rivero, M., … Gradin, V. B. (2017). Effect of self-esteem on social interactions during the Ultimatum Game. Psychiatry Research, 252, 247–255. https://doi.org/10.1016/j.psychres.2016.12.063

 

2016

Gradin, V. B., Pérez, A., MacFarlane, J. A., Cavin, I., Waiter, G., Tone, E. B., … Steele, J. D. (2016). Neural correlates of social exchanges during the Prisoner’s Dilemma game in depression. Psychological Medicine, 46(6). https://doi.org/10.1017/S0033291715002834

 

2015

Gradin, V. B., Pérez, A., MacFarlane, J. A., Cavin, I., Waiter, G., Engelmann, J., … Steele, J. D. (2015). Abnormal brain responses to social fairness in depression: An fMRI study using the Ultimatum Game. Psychological Medicine, 45(6). https://doi.org/10.1017/S0033291714002347

Johnston, B. A., Tolomeo, S., Gradin, V.B., Christmas, D., Matthews, K., & Douglas Steele, J. (2015). Failure of hippocampal deactivation during loss events in treatment-resistant depression. Brain, 138(9). https://doi.org/10.1093/brain/awv177

 

2014

Sokunbi, M. O., Gradin, V. B., Waiter, G. D., Cameron, G. G., Ahearn, T. S., Murray, A. D., … Staff, R. T. (2014). Nonlinear complexity analysis of brain fMRI signals in schizophrenia. PLoS ONE, 9(5). https://doi.org/10.1371/journal.pone.0095146

Gradin, V. B., Baldacchino, A., Balfour, D., Matthews, K., & Steele, J. D. (2014). Abnormal brain activity during a reward and loss task in opiate-dependent patients receiving methadone maintenance therapy. Neuropsychopharmacology, 39(4). https://doi.org/10.1038/npp.2013.289

 

2013

Gradin, V. B., Waiter, G., O’Connor, A., Romaniuk, L., Stickle, C., Matthews, K., … Douglas Steele, J. (2013). Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia. Psychiatry Research, 211(2), 104–111. https://doi.org/10.1016/j.pscychresns.2012.06.003S0925-4927(12)00127-8 [pii]
 

2012

Gradin, V. B., Waiter, G., Kumar, P., Stickle, C., Milders, M., Matthews, K., … Steele, J. D. (2012). Abnormal neural responses to social exclusion in schizophrenia. PLoS One, 7(8), e42608. https://doi.org/10.1371/journal.pone.0042608PONE-D-12-14947 [pii]

 

2011 

Gradin, V. B., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., … Steele, J. D. (2011). Expected value and prediction error abnormalities in depression and schizophrenia. Brain, 134(6). https://doi.org/10.1093/brain/awr059
 

2010 

Gradin, V.B., Gountouna, V.-E., Waiter, G., Ahearn, T. S., Brennan, D., Condon, B., … Steele, J. D. (2010). Between- and within-scanner variability in the CaliBrain study n-back cognitive task. Psychiatry Research - Neuroimaging, 184(2). https://doi.org/10.1016/j.pscychresns.2010.08.010
 

2008 

Gradin, V. B., & Pomi, A. (2008). The role of hippocampal atrophy in depression: a neurocomputational approach. J Biol Phys, 34(1–2), 107–120. https://doi.org/10.1007/s10867-008-9099-7

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